Projects

Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.

Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.

Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.

Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.

Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.