Projects

Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened across 120 µs+ of all-atom and coarse-grained MD with free-energy calculations, and validated by flow cytometry and degranulation assays.

Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.

Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.

Separating sex-driven metabolic differences from the tumour burden that confounds them, across 174 samples of paired serum metabolomics and liver transcriptomics.

Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.