Projects on Boyue Zhanghttps://boyuezhang.com/projects/Recent content in Projects on Boyue ZhangHugoen-usMon, 01 Jun 2026 00:00:00 +0000Trimeric Redesign of a CAR-T Costimulatory Transmembrane Domainhttps://boyuezhang.com/projects/procar3-trimer/Mon, 01 Jun 2026 00:00:00 +0000https://boyuezhang.com/projects/procar3-trimer/Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.Computational Design of CrtW and CrtZ for Enhanced Astaxanthin Biosynthesishttps://boyuezhang.com/projects/crtw-enzyme/Mon, 01 Sep 2025 00:00:00 +0000https://boyuezhang.com/projects/crtw-enzyme/Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.LumaManta — Programmable Biosensing for Water Monitoringhttps://boyuezhang.com/projects/igem-lumamanta/Thu, 01 Aug 2024 00:00:00 +0000https://boyuezhang.com/projects/igem-lumamanta/Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.Sex Dimorphism in DEN/TCPOBOP-Induced Hepatocellular Carcinomahttps://boyuezhang.com/projects/hcc-multiomics/Sun, 01 Mar 2026 00:00:00 +0000https://boyuezhang.com/projects/hcc-multiomics/Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.A Sustainable Pigment Biosynthesis Systemhttps://boyuezhang.com/projects/srtp-pigment/Sat, 01 Mar 2025 00:00:00 +0000https://boyuezhang.com/projects/srtp-pigment/Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.