Molecular Dynamics

Trimeric Redesign of a CAR-T Costimulatory Transmembrane Domain
Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call
WEHI Call Lab 2026 Ongoing
Program
Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.
protein engineering structural biology molecular dynamics
Computational Design of CrtW and CrtZ for Enhanced Astaxanthin Biosynthesis
Supervised by Dr. Yangwei Jiang · PI: Prof. Ruhong Zhou
ZJU Zhou Lab 2025 Ongoing
Code
Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.
enzyme engineering protein design molecular dynamics
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