Molecular Dynamics on Boyue Zhanghttps://boyuezhang.com/tags/molecular-dynamics/Recent content in Molecular Dynamics on Boyue ZhangHugoen-usMon, 01 Jun 2026 00:00:00 +0000Trimeric Redesign of a CAR-T Costimulatory Transmembrane Domainhttps://boyuezhang.com/projects/procar3-trimer/Mon, 01 Jun 2026 00:00:00 +0000https://boyuezhang.com/projects/procar3-trimer/Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.Computational Design of CrtW and CrtZ for Enhanced Astaxanthin Biosynthesishttps://boyuezhang.com/projects/crtw-enzyme/Mon, 01 Sep 2025 00:00:00 +0000https://boyuezhang.com/projects/crtw-enzyme/Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.