Protein Engineering Trimeric Redesign of a CAR-T Costimulatory Transmembrane DomainSupervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa CallWEHI Call Lab 2026 OngoingProgramRedesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.protein engineering structural biology molecular dynamics▾